منابع مشابه
Colorectal polyposis and inherited colorectal cancer syndromes
The majority of colorectal cancer (CRC) cases are sporadic, with hereditary factors contributing to approximately 35% of CRC cases. Less than 5% of CRC is associated with a known genetic syndrome. Although adenomatous polyposis syndromes, hamartomatous polyposis syndromes, and those previously classified as non-polyposis CRC syndromes are quite rare, it is important for clinicians to know the c...
متن کاملInherited Colon Cancer Syndromes
MEREDITH C. ROATH, MD JACK A. DI PALMA, MD University of South Alabama T he modern age of genetics began in the mid-19th century, and many scientific discoveries led to the sequencing of the human genome. Recent research has uncovered the genetic basis of many diseases, and continued study is certain to lead to more discoveries. The results of this research will continue to change medicine. Gen...
متن کاملInherited cancer susceptibility syndromes in paediatric practice.
Over the last decade there have been rapid advances in our knowledge about the molecular basis of many inherited disorders. Molecular testing is now available for many conditions and may assist in the management of the individual and their extended family. One area where the use of genetic testing has expanded rapidly is in the area of hereditary cancer, particularly in relation to hereditary b...
متن کاملDeciphering the molecular pathways disrupted in normal and neoplastic colonic tissue in inherited colorectal cancer syndromes
Background Genetic profiling by RNA microarray of normal and neoplastic colonic tissue is used to identify biomarkers for development of a diagnostic tool for the inherited colon cancer syndromes. The utility of this method is to 1) properly classify patients where genetic diagnosis is incomplete 2) suggest molecular pathways that are shared between the syndromes and 3) identify molecular targe...
متن کاملThe Mendelian colorectal cancer syndromes
A small minority of colorectal cancers (CRCs) (≤5%) are caused by a single, inherited faulty gene. These diseases, the Mendelian colorectal cancer (CRC) syndromes, have been central to our understanding of colorectal carcinogenesis in general. Most of the approximately 13 high-penetrance genes that predispose to CRC primarily predispose to colorectal polyps, and each gene is associated with a s...
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ژورنال
عنوان ژورنال: The Cancer Journal
سال: 2011
ISSN: 1528-9117
DOI: 10.1097/ppo.0b013e318237e408